Welcome Back

By becoming a RECADEMY member, you agree to site’s user

Treating Fentanyl & High-Potency Synthetic Opioid (HPSO) Use Disorder: Evidence-Based MOUD Protocols, Induction Strategies, & Harm Reduction Approaches in Real-World Care Settings

Recent CDC national data shows that while total drug overdose deaths have declined from their peak, synthetic opioids remain the dominant driver of opioid-related mortality. In the most recent finalized CDC national data, synthetic opioids were involved in roughly 70% of all overdose deaths and most opioid-related deaths.

The efficacy of methadone and buprenorphine is well established. CDC national data and NIDA continue to affirm that medications for opioid use disorder are associated with significant reductions in both overdose and all-cause mortality, and that retention in treatment is strongly associated with survival. In fact, federal guidance often summarizes the impact this way: treatment with methadone or buprenorphine can reduce the risk of death by at least half.  

The question is no longer whether MOUD works.  The more pressing question is whether our clinical protocols, operational workflows, workforce competencies, and reimbursement models have kept pace with the fentanyl era. 

Fentanyl is not only a clinical challenge.  It is a system design challenge.  That is what we will explore in this webinar.

Key Topics Include:

  • How should induction strategies evolve in high-fentanyl exposure settings? 
  • When should methadone be prioritized for patients with very high tolerance? 
  • How should low-dose or flexible induction strategies be implemented safely and consistently? 
  • How do we embed harm reduction into core system infrastructure rather than treating it as an adjunct? 
  • How do we manage fentanyl combined with stimulants and other substances? 
  • And how do we scale these approaches across large public systems under workforce shortages and financial pressure?

Speakers

Brian Hurley MD, MBA, FAPA, DFSAM

,

Los Angeles County Department of Public Health’s Bureau of Substance Abuse Prevention and Control 

Read More

Stuart Buttlaire Ph.D

,

OPEN MINDS

Read More

Tuesday, March 31st

11:00 am ET to 12:00 pm ET

Online Webinar

Link Available for Attendees

Event Details: Everything inside this box will not show on the front end but will be used by the event template

March 31, 2026 @ 11:00 am 12:00 pm